NAFLD Clinical Research Archives - AZ Clinical Trials

Read more in our blog about the latest NAFLD research

The Latest Research for NAFLD!

November 29, 2021 No Comments

In the medical world, we are always trying to find new ways to treat all kinds of conditions. Non-alcoholic fatty liver disease, or NAFLD, is a condition that we are constantly learning more about, especially in the work of clinical research. NAFLD has emerged as the most prominent cause of chronic liver disease. So what’s new in NAFLD research? Let’s find out! PUBLIC SERVICE ANNOUNCEMENT! NAFLD researchers are urging the public to take care of themselves by declaring NAFLD as a public health priority. They are realizing that the general public does not possess proper knowledge of NAFLD and they desire to change that. At the Digital NAFLD Summit 2021, researchers developed a final set of 37 consensus statements and 26 recommendations. The statements addressed a broad range of topics relevant to policymakers, practitioners, civil society groups, researchers, and affected populations. They hope that these recommendations can bring major change to NAFLD basic knowledge and prevention. Who Has a Higher Risk of Getting NAFLD? Anyone can develop NAFLD. Unfortunately, we don’t know everything about this condition. However, clinical research has provided a lot of information about who can get it or what causes fatty liver. We do know that it is more common for people that have the following factors: Type 2 diabetes and prediabetes Obesity Middle-aged or older Hispanic High levels of fats in the blood High blood pressure Take certain drugs Have certain metabolic disorders Experienced rapid weight loss Have certain infections, such as hepatitis C Were exposed to toxins NAFLD Treatment and Prevention There is no medication or vaccine approved by the FDA to treat NAFLD. Fortunately, there are ways in which you can reduce or prevent fatty liver. Common suggestions from physicians include: Losing weight Get regular exercise Eating a healthy diet that reduces salt and sugar intake Get vaccinated for hepatitis A and B, the flu, and pneumococcal disease NAFLD clinical research is so crucial today. We need clinical trials to develop treatments for NAFLD and you can help us. Participate in clinical trials to help the advancement in medicine for NAFLD. You can sign up for our current or upcoming studies by calling us at (480) 360-4000 or visiting our website. Sources: https://www.healio.com/news/hepatology/20210924/six-recent-reports-from-the-digital-nafld-summit-2021 https://www.healio.com/news/hepatology/20210917/researchers-deem-nafld-a-public-health-priority https://easl.eu/press-release/treatment-advances-for-non-alcoholic-fatty-liver-disease-nafld-announced-at-ilc-2021/ https://atriumhealth.org/about-us/newsroom/news/2021/04/groundbreaking-clinical-trials-for-patients-with-nonalcoholic-fatty-liver-disease https://medlineplus.gov/fattyliverdisease.html

From Vaccines to Boosters

November 11, 2021 No Comments

We are a little over a month away from the first anniversary of when the first COVID-19 vaccine dose was given. Over 15 million fully vaccinated Americans later, a lot has taken place in these last 11 months. Here’s the recap from vaccines to boosters in the fight to end COVID-19. Vaccines, Efficacy, and Age Groups In the U.S., there are three vaccines currently in circulation. Several others are still under evaluation in clinical trials. Let’s look at the latest efficacy reports and which age groups are approved to take them: Pfizer- BioNTech : 2 doses, 21 days apart. Approval Status: FDA approved in August 2021 for ages 16 and up. Emergency use authorization (EUA) for ages 5-15 Effectiveness: Full effectiveness 2 weeks after 2nd 91% effective at preventing COVID-19, and 89% effective in preventing severe disease. Approved ages: Children and adults 5 and older Moderna: 2 doses, 28 days apart. Approval Status: Under EUA since December 2020. Effectiveness: Full effectiveness 2 weeks after 2nd 94% effective at preventing COVID-19, and 90% effective in preventing severe disease. Approved ages: Adults 18 and older. Johnson & Johnson: Single dose. Approval Status: Under EUA since February 2021. Effectiveness: Full effectiveness 2 weeks after single dose. 66% effective at preventing COVID-19, and 85% effective in preventing severe disease. Approved ages: Adults 18 and older. Boosters Being vaccinated is still possibly the most important way we can get past the COVID-19 pandemic. As more time passes, we continue to learn more about whether or not booster doses would be beneficial. It’s important to mention, boosters are not a new idea and do not mean anything is wrong with the vaccine. If vaccine immunity wanes after some time, a booster helps prolong protection. Several routine immunizations require booster doses, these include chickenpox, tetanus, diphtheria, and mumps. The CDC recommends a booster dose of the Pfizer and Moderna vaccine 6 months after the last dose for people 65 and up. In addition, it covers residents of long-term care settings, people 18 to 64 with underlying medical conditions, and those whose work may put them at higher risk of exposure to COVID-19. People with certain immunocompromising conditions can get a third dose of the Pfizer or Moderna vaccines two months after completing their 2nd dose. CDC interim guidelines recommend moderately and severely immunocompromised people who received one dose of the Johnson & Johnson vaccine get a second dose of either an mRNA or J&J vaccine at least two months after their initial shot. Help Us End COVID-19 The fight to end COVID-19 is still ongoing. Here at Arizona Liver Health, we are looking for individuals to join COVID-19 studies looking into potential new options. We offer FREE COVID-19 testing and provide other study opportunities for healthy individuals and those diagnosed with COVID-19. Call us today to learn more at (480) 360-4000, or visit our website. Sources: https://www.yalemedicine.org/news/covid-19-vaccine-comparison

Liver Awareness Month

October 14, 2021 No Comments

The liver is one of the most vital organs in our bodies. It is impossible to survive without the life-sustaining functions it provides. Understandably, how well we take care of our liver impacts its ability to function properly. National Liver Awareness Month is an annual designation occurring in October to create awareness around liver health. By giving it the attention it deserves, we can stay healthy for as long as possible. Why the Liver is Important The liver is the second largest organ in your body and is located right under your rib cage on your right side. Your liver processes what you consume and breaks it down into nutrients your body uses. It also: Cleans your blood of toxins Gives you energy Produces bile for digestion Causes of Liver Disease There are over 100 different diseases that can damage the liver. Nevertheless, most damage the liver in similar ways and follow the same progression. The common causes of liver disease include: Viruses Genetics Autoimmune disease Excessive abuse of alcohol Unhealthy diet and obesity Medication side effects, illegal drugs, or toxic chemicals National Liver Awareness Month Liver disease affects from 50 million to 100 million individuals globally. Numerous diseases pose an increasing concern, such as liver cancer, nonalcoholic fatty liver disease (NAFLD), and hepatitis. Liver cancer is the third leading cause of cancer-related deaths in America. Despite the growing prevalence, there is hope. With early detection and treatment, the progression can be stopped or reversed. Those at risk of developing liver disease can also potentially prevent its onset. Start taking care of your liver today. You can celebrate National Liver Awareness Month by taking some simple steps towards liver health, such as: Work towards achieving and maintaining a healthy weight. Eat healthier by avoiding high-calorie meals, refined carbohydrates like white bread/enriched flour, and eat a good amount of fiber. Exercise regularly up to 5 days a week for at least 30 minutes a day. Use alcohol responsibly. Avoid using drugs. Follow prescribed directions on all your medications. Get vaccinated for hepatitis A and B. Are you concerned about your risk of liver disease? Arizona Liver Health can help! We offer FREE liver scans using fibroscan technology for adults at risk of developing liver disease. A fibroscan is a quick, painless way to determine liver health. Individuals whose results indicate the presence of liver disease will also have an option to learn more about our enrolling liver research studies. Schedule your appointment today! Call us at (480) 470-4000, or visit our website for more details and online request form. Sources: https://nationaltoday.com/national-liver-awareness-month/ https://nationaldaycalendar.com/national-liver-awareness-month-october/ https://liverfoundation.org/for-patients/about-the-liver/the-progression-of-liver-disease/

Signs That You May Have Already Had COVID-19

September 15, 2021 No Comments

COVID-19 has affected the lives of millions of people around the world since late 2019. You can also be asymptomatic, meaning you have no symptoms but still are carrying the virus. With this in mind, a lot of people have been asking themselves if they have already had the virus because some of the symptoms are similar to the common cold. We’ve come up with a list of signs and symptoms that could indicate whether you may have already had COVID-19 without realizing it. Symptoms of COVID-19 Unfortunately, there’s no way to be 100% certain whether the bad cold you developed last season was COVID-19, but here are some possible signs that you may have already had coronavirus. Cough – Do you have a cough that won’t go away? The CDC reported over 40% of people experienced a dry cough for weeks after having COVID. Fatigue – Fatigue is one of the biggest lingering effects after COVID-19. New loss of taste or smell – Loss of taste or smell is a hallmark symptom of COVID. While it’s possible to experience this with other respiratory illnesses, If you experienced this at any point, you may have had COVID-19. Shortness of breath or trouble breathing – Lasting inflammation in the lungs can be cause for shortness of breath or trouble breathing. Other symptoms that are all associated with COVID-19 include body aches, stuffy nose or runny nose, fever or chills, headache, and sore throat. Testing for COVID-19 In addition to knowing the symptoms of COVID-19, you should know the various tests available for the virus. There are two forms of testing for COVID-19: a viral test or an antibody test. The viral test shows if you currently are carrying the virus. The antibody test shows any past exposure to COVID-19. An antibody test is not recommended to assess immunity after a COVID-19 vaccination. Click here to learn more about testing for COVID-19 and to find out where you can get tested at a testing site near you. Please note that just because you may have had these symptoms, does not mean you had COVID-19. The only sure way of knowing is by undergoing testing specifically for the COVID-19 virus. If you believe you might have COVID-19, FREE testing is available at Arizona Clinical Trials. If you know that you have COVID-19, consider looking into clinical trials that may be an option. Clinical trials are important for the future of overcoming COVID-19. Participating in a COVID-19 clinical allows you to be a part of history. Helping evaluate future treatments for COVID-19 is vital to improving the lives of those living with this virus. Are you interested in COVID-19 clinical trials or getting a free COVID-19 test? Learn more by clicking here. Sources: https://www.healthline.com/health/sure-signs-you-ve-already-had-covid#signs

From Liver Disease to Cirrhosis

August 26, 2021 No Comments

Cirrhosis is when the permanent scarring of the liver has replaced the healthy tissue. While cirrhosis is most often associated with chronic alcohol consumption, it is brought about by many types of liver disease. Here’s how you get from liver disease to cirrhosis. Inflammation to Fibrosis When you have liver disease, the liver enters into a perilous cycle to heal itself. The immune system sends the signal to repair cells triggering chronic inflammation and to continue depositing collagen. In a healthy liver, the collagen stiffens around the tissue, and any extra is discarded. However, with liver disease, there is no signal to stop the inflammation discarding the excess collagen. So, the inflammation and more deposits of collagen continues. This leads to more liver stiffening and the development of fibrosis. Fibrosis is when collagen and other proteins build up between the cells. This forms scar tissue which can block or limit blood flow within the liver, eventually starving and killing healthy liver cells. More scar tissue forms, and unlike healthy liver cells, it cannot function or repair itself. Fibrosis to Cirrhosis While fibrosis is reversible even into the later stages of liver disease, there is a point where the damage is too significant, and the liver can’t fix itself. No treatment can cure cirrhosis; by staying away from things that could harm your liver further, like liquor, certain drugs, and fatty food, you can help improve some of the scarrings. Treatment for individuals with cirrhosis includes managing its symptoms and treating the underlying cause to prevent liver function from worsening or liver failure. Those with cirrhosis have a high risk of developing liver cancer and eventually needing a transplant. Our livers are versatile, continuing to work even when they’ve become seriously scarred. Most individuals with liver disease do not know it until routine blood work picks it up or symptoms become present in the later stages. Talk with your doctor about preventative measures you can take if you’re at risk of liver disease. Arizona Liver Health offers FREE fibroscans for adults at risk of liver disease. A fibroscan is a quick way to determine the health of your liver and the presence of liver disease. Should your results indicate fatty liver or other liver conditions, our staff will talk with you about enrolling studies that may be an option. To learn more, call us at (480) 470-4000, or fill out a request form online today! Sources: https://www.webmd.com/digestive-disorders/understanding-cirrhosis-basic-information https://liverfoundation.org/for-patients/about-the-liver/the-progression-of-liver-disease/#cirrhosis-severe-scarring

Calling all caregivers! Read our latest blog on tips for being a caregiver of someone with liver disease

Tips for Caregivers

August 4, 2021 No Comments

Having liver disease affects the person with it but also loved ones around them. Often a family member or friend fills the role of meeting a variety of physical and emotional needs. If you are a caregiver for someone with liver disease, here are some tips to help you feel better prepared to handle your loved ones’ needs. Caregivers Help When Necessary Most who care for a loved one with liver disease don’t consider themselves a “caregiver” initially. In reality, you play an essential role in your loved one’s life by lending a hand with the following. Daily Tasks Feeding, bathing, grooming, and dressing. Cleaning, cooking/meal preparation, and running errands. Manage finances/provide financial support Emotional support and companionship Medical Tasks Keeping medication schedules on time. Examples are giving reminders of dose times. Also, keeping track of supply and need for refills. Recognizing signs and symptoms of worsening liver disease, as well as medication side effects. Manage medical records and schedule their medical appointments. Provide transportation to appointments, shopping, and other events. Helpful Tips for Managing Caregiver Demands A caregiver manages their loved one’s daily life. Likewise, you are also managing your own family and personal needs. Here are some tips developed from expert advice and others who have cared for those with liver disease: Daily Ask for help from other family members or friends to help avoid caregiver burnout. Take care of your physical and emotional health too. Take time daily to break away and do something that brings you joy. The better you care for yourself, the better you can care for your loved one. Learn as much as you can about their condition. This way, you become informed of the best ways to help them thrive. Emotions Take one day at a time and learn ways to manage stress better. Understand that frustration from your loved one isn’t purposeful or personal. Contact your benefits advisor at your workplace to verify what support resources are available. Including free counseling sessions, legal aid, etc. Build a support network to connect with others who are going through the same experiences that you are. Medical Ensure your healthcare provider has given you a complete understanding of the information provided in each appointment. Talk to your healthcare provider about arranging home care services if needed. Finances Check with your bank or financial advisor to review any short-term solutions to help with any financial changes causing strain. Meet with other family members to involve everyone in future planning, more importantly, to better allocate financial responsibilities. Having liver disease and needing the help of a caregiver can be challenging. Your loved one may feel defeated and a burden on you and other loved ones. Participating in clinical research studies can help them give back by advancing medicine for liver disease. Volunteering has been shown to counteract symptoms of anxiety, depression and boost confidence. If your loved one has liver disease, enrolling liver disease research studies here at Arizona Liver Health may be an option. For more information, call us at (480) 470-4000, or visit our website. Sources: https://www.liver.ca/patients-caregivers/for-caregivers/ https://liverfoundation.org/caregivers/tips-for-caregivers/

Not sure if you're symptoms are COVID-19 related?

COVID: Know When to Get Tested

July 29, 2021 No Comments

49.2% of the U.S. population is fully vaccinated against COVID-19 at the current writing of this blog. After months of decline, new cases are rising again. In part, thanks to things like the delta variant, vaccine hesitancy, and July 4th gatherings. If anything, the rise in cases should solidify the fact the COVID-19 is still prevalent. Therefore, we should still know the symptoms and when to get tested at the very least. So, here’s your updated refresher. COVID-19 Symptoms COVID-19 has a wide range of symptoms. Some only get mild symptoms, and others develop severe illness. Symptoms typically appear anywhere from 2-14 days after exposure to the virus. Common symptoms include: Fever or chills Cough Shortness of breath or difficulty breathing Fatigue Muscle or body aches Headache New loss of taste or smell Sore throat Congestion or runny nose Nausea or vomiting Diarrhea As far as the delta variant, we are still learning about it. Unfortunately, this means there is a limit to the information available. We know that it seems to spread faster than the alphavirus variant first detected in Wuhan, China. So far, studies suggest that authorized vaccines offer strong protection against severe disease and death from the delta variant. As scientists and researchers continue efforts to understand these variants better, more information will become available. When to Test, and When not To. Anyone should undergo testing who is experiencing symptoms, regardless of their vaccination status. Other situations warrant testing if you don’t have COVID-19 symptoms. According to the CDC, if you don’t have symptoms and are not fully vaccinated, you should still be tested if you: Had close contact with someone with confirmed COVID-19, This is including someone who does not have symptoms within ten days of their positive test result. Are an individual who’s taken part in activities that put you at higher risk for COVID-19. Attending large social or mass gatherings or being in crowded indoor settings are examples. Belong to a prioritized group for expanded community screening for COVID-19. Have been asked or referred to get testing by your school or workplace. If you are a healthcare provider or a member of a state, tribal, local, or territorial health department. You can find the interim recommendations for fully vaccinated individuals here. Are you Experiencing COVID-19 Symptoms? If you’re experiencing COVID-19 symptoms, we can test you for FREE here at Arizona Clinical Trials. Those with a positive test may be eligible to participate in enrolling COVID-19 clinical trials. Don’t delay; we can test you today! Call (480) 360-4000 to schedule your appointment, or visit our website to learn more! Sources: https://www.cdc.gov/coronavirus/2019-ncov/symptoms-testing/symptoms.html https://www.worldometers.info/coronavirus/ https://www.cdc.gov/coronavirus/2019-ncov/symptoms-testing/testing.html https://www.washingtonpost.com/health/2021/07/07/delta-variant-covid/

Liver Disease and the Hispanic Population

July 13, 2021 No Comments

The number of U.S. adults with non-alcoholic fatty liver disease (NAFLD) currently sits around 25%. Approximately 2-3% of them will go on to develop non-alcoholic steatohepatitis (NASH). NASH is a more severe form of NAFLD and can lead to fibrosis, cirrhosis, and liver failure. By 2030, it is estimated this number will increase from 2-3% to up to 63%. Among the ethnic groups affected, Hispanic populations face the most significant risk of liver disease. Here’s why. Dangers of NASH and Prevalence in Hispanics NASH often stems from high-sugar, high-fat diets. To compensate, our livers begin storing excess fat. If nothing changes, inflammation occurs over time. Eventually, the inflammation progresses to cirrhosis, liver failure, liver cancer, the need for a liver transplant, and even death. NASH also has a close association with other conditions such as heart disease, which is the leading cause of death in patients. Thirty million Americans have NASH. The problem is most don’t know it because there typically aren’t any symptoms. Liver disease is a top cause of death among Hispanics, with NAFLD being among the most prevalent type. Hispanics are more often diagnosed in more advanced stages of liver disease and less likely to get help. Hispanic mortality rates are double that of other races. Risk Factors Multiple factors are contributing to the disproportionate effects of liver disease on Hispanics. Each element is also a top cause of fatty liver disease. These include: 43% of Hispanics in the U.S. are considered obese 35% of Hispanics in the U.S. have metabolic syndrome Diets high in carbohydrates and sugar Many Hispanics possess the gene variation PNPLA3, which is associated with a heightened risk of NAFLD and NASH The predisposition of Hispanics to these multiple risk factors further increases their risk higher than other ethnicities. Be Proactive with Your Liver Health By knowing the risk, Hispanic individuals can take steps to protect their liver health proactively. You can work with your doctor to routinely check your liver for any changes. Those with NAFLD or NASH can slow, stop, or reverse disease progression through healthier lifestyle changes. Prevention is also possible for at-risk individuals. Here are three lifestyle changes you can start immediately: Maintaining a healthy weight Eating a well-balanced, sensible diet Exercising moderately at least five days a week for 30 minutes or longer Lifestyle changes are the basis of liver disease treatment and prevention. By reversing the same behaviors that contribute to this condition, you can make a big impact on a healthier, better-functioning liver. The liver is a regenerative organ and can heal itself if caught in time. Don’t wait! Arizona Liver Health offers FREE fibroscans for adults at risk of liver disease. A fibroscan is a test that detects the stiffness in a liver to determine fatty liver disease or other conditions. It’s a quick, painless way to evaluate the health of your liver, and the results are immediate. There’s no cure for NASH. As a result, potential treatment options are under investigation in clinical research studies. If your results show the presence of liver disease, our team with review enrolling study options that may help. Schedule your FREE fibroscan today! Call us at (480) 470-4000, or request an appointment online. Sources: https://txliver.com/media/hispanics-and-liver-disease/ https://salud-america.org/the-silent-liver-disease-epidemic-among-latinos/

The End of Quarantine?

June 18, 2021 No Comments

Since the beginning of the COVID-19 vaccine distribution, 43.7% of Americans are now fully vaccinated. Most states have fully opened, and most have fully lifted mask mandates. Daily new cases and deaths are at a fraction of where they were previously. Nevertheless, they are still occurring. Is this the end of quarantine? Not yet. Quarantine Guidelines from the CDC Just because many people are vaccinated doesn’t mean those exposed to COVID-19 or are experiencing symptoms no longer have to quarantine. The vaccinations have changed things a little but are mainly divided into directives for fully, partially, and unvaccinated individuals. Here is what the CDC says: Unvaccinated must quarantine: 10 days since symptoms first appeared and 24 hours with no fever without the use of fever-reducing medications and Other symptoms of COVID-19 are improving. Partially vaccinated means: You have either not received your 2nd dose, or: It has not been 2 weeks since your second dose in a 2-dose series, such as the Pfizer or Moderna vaccines. It has not been 2 weeks since your single-dose vaccine, such as Johnson & Johnson’s Janssen. Partially vaccinated individuals experiencing symptoms or exposed to the virus would need to follow the standard quarantine guidelines as an unvaccinated person does. Fully vaccinated exposure to virus: You do not need to stay away from others or go through testing unless you have symptoms. Symptomatic fully vaccinated individuals will then follow the standard quarantine guidelines listed under unvaccinated individuals. Herd Immunity and Continuing the Fight Herd immunity became a buzzword when cases skyrocketed last year. It means the number of people in a population who can get the disease drops to such a low level that any new cases cannot spread. The problem is that accomplishing herd immunity means isolating people with symptoms and isolation from any new factors altering what we know about the disease. Neither of which is present in COVID-19. Variations in the virus and vaccine hesitancy further challenge the reality of reaching herd immunity. The reduction in cases and deaths is directly related to vaccine distribution and emerging treatments. The data gathered so far has shown vaccines are effective at preventing the virus, while treatments are helping more people to recover once they get it. Is this the end of the need for quarantine? No. If the virus has taught us anything, it’s to be respectful of each other’s health. It’s also evident that when a community unites against a public health threat, nothing’s impossible. Get involved in COVID-19 studies currently enrolling here at Arizona Liver Health. Healthy individuals, those experiencing symptoms, or have tested positive for COVID-19 are needed. Call us at (480) 360-4000 or visit our website to learn more! Sources: https://www.cdc.gov/coronavirus/2019-ncov/if-you-are-sick/end-home-isolation.html https://med.stanford.edu/news/all-news/2021/05/Herd-immunity-illusive-vaccination-best-to-stave-off-COVID-19.html

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NAFLD Clinical Research Archives - AZ Clinical Trials

The Latest Research for NAFLD!

From Vaccines to Boosters

Liver Awareness Month

Signs That You May Have Already Had COVID-19

From Liver Disease to Cirrhosis

Tips for Caregivers

COVID: Know When to Get Tested

Liver Disease and the Hispanic Population

The End of Quarantine?

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